Investigations into the use of electrokinetic capillary chromatography for the separation of macromolecular and particulate materials

Author

Suzanne Annette Landry Baker

Date of Award

5-1989

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

Michael J. Sepinak

Committee Members

Tuan Vo-Dinh

Abstract

The separation of particulate materials by a new technique resulting from a combination of capillary zone electrophoresis and hydrodynamic chromatography was investigated. This technique is referred to in this thesis as "electrodynamic capillary chromatography". Experiments involving the separation of a mixture of several different size polystyrene particles were done to determine the feasibility of this technique. Micellar electrokinetic capillary chromatography was investigated as a possible method for the separation of oligonucleotides. Enhancement of oligonucleotide separation was attempted by using several different mobile phases. Also, the incorporation of additives into these mobile phases to further enhance separation by extending the elution range was investigated.

Recommended Citation

Baker, Suzanne Annette Landry, "Investigations into the use of electrokinetic capillary chromatography for the separation of macromolecular and particulate materials. " Master's Thesis, University of Tennessee, 1989.
https://trace.tennessee.edu/utk_gradthes/12884