Source Publication
Journal of Immunology
Document Type
Article
Publication Date
January 2003
Abstract
Memory T cells are more responsive to Ag than naive cells. To determine whether memory T cells also have more efficient TCR signaling, we compared naive, effector, and memory CD8 T cells of the same antigenic specificity. Surprisingly, initial CD3 signaling events are indistinguishable. However, memory T cells have more extensive lipid rafts with higher phosphoprotein content before TCR engagement. Upon activation in vivo, they more efficiently induce phosphorylation of-LAT (linker for activation of T cells), ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase), and p38. Thus, memory CD8 T cells do not increase their TCR sensitivity, but are better poised to augment downstream signals. We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity.
Recommended Citation
Onami, Thandi M.; Kersh, Ellen N.; Kaech, Susan M.; Moran, Miriana; Wherry, E. John; Miceli, M. Carrie; and Ahmed, Rafi, "TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells" (2003). Microbiology Publications and Other Works.
https://trace.tennessee.edu/utk_micrpubs/24
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