Masters Theses

Date of Award

8-2022

Degree Type

Thesis

Degree Name

Master of Science

Major

Comparative and Experimental Medicine

Major Professor

Angela Rollins

Committee Members

Angela Rolllins, Claudia Kirk, Dallas Donohoe

Abstract

Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests consuming medium-chain triglycerides (MCT) may lower pancreatic enzyme release compared to consuming long chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod and rice with either 3% metabolizable energy (ME) fat (control), high MCT (25% ME MCT oil, 25% ME butter), high saturated LCFA (50% ME butter), or high unsaturated LCFA (50% ME canola oil) in a 4-period by 4-treatment crossover design. Serum concentrations of canine pancreatic lipase immunoreactivity, gastrin, amylase, cholecystokinin (CCK), cholesterol, triglycerides and serum activities of DGGR lipase were measured at times 0 (fasted), 30, 120 and 180 minutes post-prandial. Following a 3-or 4-day wash-out period, each dog was assigned a new diet and the process was repeated for all treatments.

Data was analyzed as a repeated-measures mixed model ANOVA. Post-hoc pairwise comparisons were run using Tukey-Kramer adjusted p-values. Shapiro-Wilk tests were used to evaluate residual normality. All statistical assumptions were sufficiently met. Statistical significance was defined as P

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