Masters Theses

Date of Award

8-2006

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

George W. Kabalka

Committee Members

Richard Pagni

Abstract

Microwave irradiation has gained in popularity in recent years since it has been found to accelerate various chemical reactions. Microwaves are generally considered to be more environmentally friendly than traditional methods for activating chemical reactions. An investigation into a microwave-enhanced, solventless Mannich condensation was performed. The efficiency of a standard household microwave was compared to that of an industrial microwave, with the industrial microwave proving to be more effective. The advantages of using microwave irradiation for a Mannich condensation include milder reaction conditions, the absence of solvent, less waste, and shorter reaction times. The reaction between terminal alkynes, secondary amines, and paraformaldehyde on Culdoped alumina, to yield β-aminoalkynes, was investigated. Cuprous iodide and alumina were both required for successful reactions. The microwave reactions produced good yields of the β-aminoalkynes.

Files over 3MB may be slow to open. For best results, right-click and select "save as..."

Included in

Chemistry Commons

Share

COinS