Solubility studies on the antibiotic penicillin V using supercritical fluids

Author

Min-Jin Ko

Date of Award

8-1989

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemical Engineering

Major Professor

Paul R. Bienkowski

Committee Members

H. D. Cochran, H. W. Hsu

Abstract

Supercritical fluid extraction is receiving widespread attention as a possible separation process for the food and pharmaceutical Industries since it can be conducted at near-ambient conditions with non-toxic solvents. This study is concerned with investigating the feasibility of separation and isolation of penicillin V using supercritical fluids. A flow apparatus has been constructed and used to determine the high pressure solid-fluid equilibrium solubilities. An absorption spectroscopic method is used to analyze the sample solutions. The solubility of penicillin V in supercritical Carbon dioxide has been measured from 314.85 K to 334.85 K and from 1144 psig to 4050 psig. The solubility ranges from 5.2 x 10^{5 to 5.6 x 104 mole fraction. It was determined that penicillin V can dissolve In supercritical carbon dioxide at concentrations 106-108 greater than that predicted by the ideal gas law. The problems associated with penicillin V and mixed solvents are discussed. The equilibrium solubility is correlated using a compressed gas model with the Peng-Robinson equation of state. The unknown physical properties of penicillin V are estimated using group contribution methods. This model correlates penicillin V solubilities within about 60 %.}

Recommended Citation

Ko, Min-Jin, "Solubility studies on the antibiotic penicillin V using supercritical fluids. " Master's Thesis, University of Tennessee, 1989.
https://trace.tennessee.edu/utk_gradthes/12990