The development and characterization of a macrocyclic polyaminocarboxylic acid and its metal complexes as potential nuclear magnetic resonance imaging agents

Author

Charles Wadley

Date of Award

8-1991

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

Clifton Woods

Abstract

Diethylenetriaminepentaacetatogadolinium(III) [Gd(III)DTPA] is currently undergoing clinical trials as a magnetic resonance imaging (MRI) agent due to its remarkably high stability in-vitro and because of its high relaxivity (R₁) value. The goal of this research was to synthesize and characterize a new macrocyclic polyaminocarboxylic acid whose Fe(III), Gd(III), and Mn(II) complexes would exhibit comparable stabilities in-vitro as well as comparable R₁ values to the diethylenetriamine pentaacetic acid (DTPA) analogues. By obtaining and comparing the R₁ values of metal complexes of 1,4,7,10,13,16-hexaazacyclooctadecane- N,N',N'' ,N'' ', N'''' ,N'"" - hexaacetic acid(OHA)w ith those of the DTPA analogues, this research qualifies the excellent potential of metal OHA complexes to be effective clinically as MRI agents.

Recommended Citation

Wadley, Charles, "The development and characterization of a macrocyclic polyaminocarboxylic acid and its metal complexes as potential nuclear magnetic resonance imaging agents. " Master's Thesis, University of Tennessee, 1991.
https://trace.tennessee.edu/utk_gradthes/12551