Synthesis of sterically hindered 5'-esters of 6-chloro-9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)purine as anti-HIV agents

Author

Farhad Azizbigloo

Date of Award

12-1997

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

David C. Baker

Committee Members

John Bartmess, Frederick Grimm

Abstract

The purpose of this research was to synthesize sterically hindered 5'-esters of 6-chloro-9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)purine as a prodrug of the anti-HIV drug ddl, expecting to show resistance to intestinal ADA and intestinal esterase enzymes and consequently higher oral bioavailability.

Recommended Citation

Azizbigloo, Farhad, "Synthesis of sterically hindered 5'-esters of 6-chloro-9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)purine as anti-HIV agents. " Master's Thesis, University of Tennessee, 1997.
https://trace.tennessee.edu/utk_gradthes/10453