Doctoral Dissertations
Date of Award
8-2007
Degree Type
Dissertation
Degree Name
Doctor of Philosophy
Major
Chemistry
Major Professor
George W. Kabalka
Committee Members
Richard Pagni, Bin Zhao, Narendra Dahotre
Abstract
Boron neutron capture therapy (BNCT) is a binary form of cancer treatment wherein 10B nuclei, when irradiated with thermal neutrons, produce high energy transfer particles. These particles, due to their size and energy, are confined to a radius of 9-10μm, which is comparable to the size of single cell. Potential BNCT agents reported in the literature include boron-containing amino acids, nucleic acids, nucleosides, antibodies, and other biomolecules.
In recent years, microwaves have gained importance in organic chemistry. Microwave induced reactions are energy efficient, often enhance reaction rates, and generally lead to enhanced product yields. Recent studies have shown that potassium organotrifluoroborates offer solutions to a number of problems that sometime occur in organoboron coupling reactions.
This dissertation describes the synthesis of novel unnatural boronated amino acids as potential BNCT agents. The new microwave enhanced synthetic methodologies developed in this dissertation are important transformations in modern organic chemistry. Mild reaction conditions, short reaction times, and tolerance for various functional groups are advantages of these methodologies.
Recommended Citation
Naravane, Abhijit Achyut, "Synthesis of Novel Boronated Amino Acids for BNCT an Alternate Cancer Therapy and Use of Microwaves in Organic Synthesis. " PhD diss., University of Tennessee, 2007.
https://trace.tennessee.edu/utk_graddiss/4246