Doctoral Dissertations
Date of Award
12-1961
Degree Type
Dissertation
Degree Name
Doctor of Philosophy
Major
Chemistry
Major Professor
David A. Shirley
Committee Members
J. Robertson, J.F.E., John W. Heuherger
Abstract
Summary
The consideration of the medical importance of phenothiazine derivatives and the known cancer chemotherapeutic value of the nitrogen mustards made the synthesis of some nitrogen mustard derivatives of the phenothiazines of particular interest. In the course of this research the N-{2-[bis-(2-chloroethyl)amino]ethyl} derivatives of phenothiazine, 7H-benzo[c]phenothiazine, 7H-dibenzo[c, h] phenothiazine, and 14H-dibenzo[a, h] phenothiazine were synthesized for anticancer evaluation. Also submitted to the Cancer Chemotherapy National Service Center for testing were the N-(2-chloroethyl) monofunctional nitrogen mustard derivatives of the first three phenothiazines mentioned above.
Recommended Citation
Gilmer, John Charles, "Some Reactions of Phenothiazine and Certain Benzophenothiazines. " PhD diss., University of Tennessee, 1961.
https://trace.tennessee.edu/utk_graddiss/3056