Source Publication (e.g., journal title)
Scientific Reports
Document Type
Article
Publication Date
10-13-2017
DOI
10.1038/s41598-017-13519-5
Abstract
Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by upregulated expression of the adipogenic regulator PPARGand its co-activator PPARGC1B, and reduced expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. These results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development.
Recommended Citation
Ronique C. Beckford, Sarah J. Howard, Suchita Das, Abigail T. Farmer, Shawn R. Campagna, Jiali Yu, Robert L. Hettich, Jeanna L. Wilson & Brynn H. Voy. “Maternal Consumption of Fish Oil Programs Reduced Adiposity in Broiler Chicks.” Scientific Reports 7 (2017). http://doi.org/10.1038/s41598-017-13519-5.
Submission Type
Publisher's Version
Comments
This article was published openly thanks to the University of Tennessee Open Publishing Support Fund.
Licensed under a Creative Commons Attribution 4.0 International license.