The synthesis of pyrimidine nucleotide analogs

Author

Ehab Ahmed Abourashed

Date of Award

12-1993

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

David C. Baker

Committee Members

Ronald M. Magid, John E. Bartmess,

Abstract

The herpes simplex virus (HSV) and the human immunodeficiency virus (HIV) are two prime targets for developing new effective antiviral drugs. A synthetic route was developed for preparing two nucleotide analogs, 3a and 3b, needed for the biochemical studies of HSV infections. Another synthetic route for the preparation of a prospective anti-HTV lypophilic D4T nucleotide analog, 7, was also developed.

Recommended Citation

Abourashed, Ehab Ahmed, "The synthesis of pyrimidine nucleotide analogs. " Master's Thesis, University of Tennessee, 1993.
https://trace.tennessee.edu/utk_gradthes/11817