Title
A Copper Cofactor for the Ethylene Receptor ETR1 from Arabidopsis
Document Type
Article
Publication Date
2-1999
Abstract
The ETR1 receptor from Arabidopsis binds the gaseous hormone ethylene. A copper ion associated with the ethylene-binding domain is required for high-affinity ethylene-binding activity. A missense mutation in the domain that renders the plant insensitive to ethylene eliminates both ethylene binding and the interaction of copper with the receptor. A sequence from the genome of the cyanobacterium Synechocystis sp. strain 6803 that shows homology to the ethylene-binding domain of ETR1 encodes a functional ethylene-binding protein. On the basis of sequence conservation between the Arabidopsis and the cyanobacterial ethylene-binding domains and on in vitro mutagenesis of ETR1, a structural model for this copper-based ethylene sensor domain is presented.
Recommended Citation
A Copper Cofactor for the Ethylene Receptor ETR1 from Arabidopsis. Fernando I. Rodríguez, Jeffrey J. Esch, Anne E. Hall, Brad M. Binder, G. Eric Schaller, and Anthony B. Bleecker. (12 February 1999) Science 283 (5404), 996.