Doctoral Dissertations
Date of Award
5-2015
Degree Type
Dissertation
Degree Name
Doctor of Philosophy
Major
Chemistry
Major Professor
George W. Kabalka
Committee Members
John Bartmess, Robert Compton, Jim Hall
Abstract
This research study is focused on the syntheses of radiotracers for use in positron emission tomography [PET] via fluorodenitration and fluorodehalogenation under microfluidic conditions. Methodology has been developed for radiolabeling via fluorodenitration under microfluidic conditions and comparisons made to dehalogenation reactions. Developmental work was carried out on commercially available compounds containing a variety of functional groups. Subsequent production of radiotracers has been performed with precursors provided by collaborators as well as those synthesized in our laboratory.
Recommended Citation
Moore, Thomas Madison, "Microfluidic Syntheses of PET Radiotracers via Fluorodenitration. " PhD diss., University of Tennessee, 2015.
https://trace.tennessee.edu/utk_graddiss/3310