In vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals

Source Publication

Sensors

Authors

Dan M. Close
Tingting Xu
Gary S. Sayler
Steven Ripp, University of Tennessee - KnoxvilleFollow

Document Type

Article

Publication Date

January 2011

Abstract

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.

doi:10.3390/s110100180

Recommended Citation

Close, Dan M.; Xu, Tingting; Sayler, Gary S.; and Ripp, Steven, "In vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals" (2011). Microbiology Publications and Other Works.
https://trace.tennessee.edu/utk_micrpubs/41