Date of Award
Doctor of Philosophy
Biochemistry and Cellular and Molecular Biology
Herman C. Lichstein
Lowell F. Bailey, William B. Cherry, J. O. Mundt, T. P. Salo, George P. Mueller
Introduction: In any study of enzymatic action in the living cell there can be no limited definition of the influences measured, since there are numerous interrelated chemical reactions, both assimilative and dissimilative, which are in a constant state of equilibrium. This circumstance has been adequately described by Dixon (1949) who states that the living cell exists as a system of unstable catalyst which in turn exist because of the occurrence of the reactions which they catalyze. Each enzyme does not maintain itself; it is rather a collective effort by a certain minimum number of enzymes which brings about the necessary series of reactions for a resynthesis. Thus it becomes necessary to study enzymatic reactions as a means of viewing life processes, but at the same time, it remains essential to study these reactions, not only as isolated crystalline moieties, but also as a particular link in a large chain of reactions.
Christman, John Francis, "The Relationship Between Biotin and the Coenzyme of Aspartic Acid, Serine and Threonine Deaminases. " PhD diss., University of Tennessee, 1950.