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  5. Automated Discovery of Pedigrees and Their Structures in Collections of STR DNA Specimens Using a Link Discovery Tool
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Automated Discovery of Pedigrees and Their Structures in Collections of STR DNA Specimens Using a Link Discovery Tool

Date Issued
May 1, 2010
Author(s)
Haun, Alex Brian  
Advisor(s)
J. D. Birdwell
Additional Advisor(s)
Tsewei Wang, David Icove
Permanent URI
https://trace.tennessee.edu/handle/20.500.14382/42604
Abstract

In instances of mass fatality, such as plane crashes, natural disasters, or terrorist attacks, investigators may encounter hundreds or thousands of DNA specimens representing victims. For example, during the January 2010 Haiti earthquake, entire communities were destroyed, resulting in the loss of thousands of lives. With such a large number of victims the discovery of family pedigrees is possible, but often requires the manual application of analytical methods, which are tedious, time-consuming, and expensive. The method presented in this thesis allows for automated pedigree discovery by extending Link Discovery Tool (LDT), a graph visualization tool designed for discovering linkages in large criminal networks. The proposed algorithm takes advantage of spatial clustering of graphs of DNA specimens to discover pedigree structures in large collections of specimens, saving both time and money in the identification process.

Subjects

DNA

pedigree

graph

link discovery

specimen

likelihood ratio

Disciplines
Bioinformatics
Other Genetics and Genomics
Degree
Master of Science
Major
Computer Engineering
Embargo Date
December 1, 2011
File(s)
Thumbnail Image
Name

Haun_Thesis.pdf

Size

8.36 MB

Format

Adobe PDF

Checksum (MD5)

c5c19af897fb9d2aebbfeb5be5e2c9d6

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