Investigation of Selectivity in Reverse Phase Liquid Chromatography . IV- Effects of Stationary and Mobile Phases on Retention of Homologous Series

Extrapolation of log k'vs. n_c plots for homologous series chromatographed with different mobile phases leads to a common intersection point. Its coordinates depend on the series and the solvent used, and can be rationalized on the basis of the retention model of interaction indices. The existence of this convergence point is reflected in the linear relationship of logagr-logbeta, which permits the optimization of chromatographic separations in the region of solvent compositions where these two parameters can be varied independently.