Halogenations using sodium halides with sodium perborate in acetic acid and allylboration of β-ketoacids

Sodium perborate is an inexpensive, stable and easy to handle reagentIn the course of a study focused on halogenation reactions, we developed a new bromination procedure using NaBr/NaBO₃ in HOAC. It provides a highly efficient, economical, and environmentally friendly method for brominating organic molecules.

In a study of allylboration reactions, we found that β-ketoacids can be easily allylboronated by β-diisopropoxyborane to yield tertiary β-hydroxyacids in good yields.