A Study of Steric Inhibition of the Pfitzinger Reaction

(From Introduction)

A survey of the Pfitzinger reaction reveals that little attention has been given to the steric factors likely to govern the course of the condensation; a major part of the research done has dealt with its value as a synthetic tool.

The primary purpose of this work was to add further information concerning steric inhibition in the Pfitzinger reaction; it was also hoped that the cinchoninic acids obtained might show physiological activity.