Source Publication (e.g., journal title)
Scientific Reports
Document Type
Article
Publication Date
9-20-2016
DOI
10.1038/srep33430
Abstract
Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, communities separated based on exposure status and became significantly different at PND 16. The ability of TCC to drive microbial dysbiosis warrants future investigation to evaluate the safety of non-prescription antimicrobial use, including TCC, during critical exposure windows.
Recommended Citation
Kennedy, R. C., Fling, R. R., Robeson, M. S., Saxton, A. M., Donnell, R. L., Darcy, J. L., ... & Chen, J. (2016). Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats. Scientific Reports, 6. doi: 10.1038/srep33430
Submission Type
Publisher's Version
Comments
This article was published openly thanks to the University of Tennessee Open Publishing Support Fund.
Licensed under a Creative Commons Attribution 4.0 International license.