Source Publication (e.g., journal title)
Frontiers in Microbiology
Document Type
Article
Publication Date
3-16-2017
DOI
10.3389/fmicb.2017.00422
Abstract
Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult and is uncommon in assessments of plant phenolic compounds. With systems biology approaches, though, antibacterial mechanisms can be assessed without the bias of target-directed bioassays to enable the discovery of novel mechanism(s) of action against drug resistant microorganisms. This review article summarizes the current knowledge of antibacterial mechanisms of action of plant phenolic compounds and discusses relevant methodology.
Recommended Citation
Rempe, Caroline S. Kellie P. Burris, Scott C. Lenaghan, and C. Neal Stewart, Jr., “The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics,” Frontiers in Microbiology 8 (2017). doi: 10.3389/fmicb.2017.00422
Submission Type
Publisher's Version
Comments
This article was published openly thanks to the University of Tennessee Open Publishing Support Fund.
Licensed under a Creative Commons Attribution 4.0 International license.