Polymer-supported reagents utilized in the synthesis of radiopharmaceuticals

Author

Karla Renee Bowers

Date of Award

12-1993

Degree Type

Thesis

Degree Name

Master of Science

Major

Chemistry

Major Professor

George W. Kabalka

Committee Members

Richard Pagui

Abstract

Single Photon Emission Computed Tomography (SPECT) is a medical imaging technique which provides three-dimensional images of living systems after infusion of radiolabeled chemical compounds. These radiolabeled pharmaceuticals must be synthesized and delivered to the patient quickly to ensure that loss of the radiolabel is minimal. This means that the synthesis and handling of the imaging agent should be efficient and as simple as possible. Current methods of radioiodination involve lengthy purification techniques usually via column chromatography. The use of polymer supported hydrides for radioiodinations could eliminate the need for such purifications by making possible the removal of polymer-bound by-products by simple filtration.

Recommended Citation

Bowers, Karla Renee, "Polymer-supported reagents utilized in the synthesis of radiopharmaceuticals. " Master's Thesis, University of Tennessee, 1993.
https://trace.tennessee.edu/utk_gradthes/11840