Date of Award

5-2015

Degree Type

Dissertation

Degree Name

Doctor of Philosophy

Major

Chemistry

Major Professor

George W. Kabalka

Committee Members

John Bartmess, Robert Compton, Jim Hall

Abstract

This research study is focused on the syntheses of radiotracers for use in positron emission tomography [PET] via fluorodenitration and fluorodehalogenation under microfluidic conditions. Methodology has been developed for radiolabeling via fluorodenitration under microfluidic conditions and comparisons made to dehalogenation reactions. Developmental work was carried out on commercially available compounds containing a variety of functional groups. Subsequent production of radiotracers has been performed with precursors provided by collaborators as well as those synthesized in our laboratory.

Files over 3MB may be slow to open. For best results, right-click and select "save as..."

Share

COinS