A gastric neuroendocrine carcinoma expressing somatostatin in a bearded dragon (Pogona vitticeps).
A metastatic gastric neuroendocrine carcinoma in a 2.5-year-old inland bearded dragon (Pogona vitticeps) with a chronic history of anorexia, weight loss, depression, and acute melena is described. Histologic examination of the gastric mass revealed a densely cellular tumor arranged in nests and occasional rosettes of hyperchromatic cells with oval to spindle-shaped nuclei and minimal cytoplasm; the tumor was supported by a moderate fibrovascular stroma. Similar cells invaded through the gastric mucosa, and there were multiple hepatic metastases. The neoplastic cells were weakly immunopositive for neuron-specific enolase and moderately positive for somatostatin but were negative for chromogranin AB and gastrin. Ultrastructural studies revealed scattered neurosecretory granules in the neoplastic cells, confirming the diagnosis of a neuroendocrine carcinoma.
Jerry Lyons, Shelley Newman, Cheryl Greenacre, and John Duncan. "A gastric neuroendocrine carcinoma expressing somatostatin in a bearded dragon (Pogona vitticeps)." Journal of Veterinary Diagnostic Investigation 22.2 (2010): 316-320.