Liquid Chromatography of Aza - Arenes
Reversed-phase liquid chromatography (RPLC) makes possible the separation of azaarenes according either to the carbon atom number, with little selectivity toward positional Isomers (long chain packlngs, methanol-water solvent mixtures), or to the position of the nitrogen atom with interferences occurring between compounds of different molecular weight (short chain packings, tetrahydrofuran and acetonitrile- water solvent mixtures). In normal-phase chromatography, the solute retention is malniy governed by the steric hindrance of the nitrogen atom.
Guiochon, Georges; Colin, Henri; and Schmitter, Jean Marie, "Liquid Chromatography of Aza - Arenes" (1981). Chemistry Publications and Other Works.