Source Publication (e.g., journal title)
7th International Congress on Farm Animal Endocrinology
Kisspeptin receptor (Kiss1r) agonists with increased half-life and similar efficacy to kisspeptin (KP) in vitro potentially may provide beneficial applications in breeding management of many species. However, many of these agonists have not been tested in vivo. This study was designed to test the effect of a Kiss1r agonist (FTM080) on luteinizing hormone (LH) in vivo. Sheep were treated with FTM080 (500 pmol/kg BW) or sterile water in a 2-ml bolus via the jugular cannula. Serial blood samples were collected every 15-min before (1 hr) and after (1 hr) treatment. Intravenous (IV) injection of FTM080 increased (P < 0.05) LH plasma concentrations through the 45-min sample following treatment. Moreover, the area under the curve of LH in the period from 0 to 60-min following FTM080 treatment was also increased (P < 0.05). These data provide evidence to suggest that FTM080 stimulates the gonadotropic axis of ruminants in vivo.
Whitlock, Brian K.; Daniel, Joseph A.; Hes, Maria; Steele, Barbara P.; Sartin, James L.; Oishi, S.; and Fujii, N., "The Effect of Kisspeptin Receptor Agonist (FTM080) on Luteinizing Hormone in Sheep" (2011). Animal Science Publications and Other Works.
Animal Sciences Commons, Endocrinology Commons, Large or Food Animal and Equine Medicine Commons, Other Neuroscience and Neurobiology Commons, Reproductive and Urinary Physiology Commons, Veterinary Physiology Commons